Article
Human Brain Ancestral Barcodes
2024-07-17
Abstract excerpt
Dynamic CpG methylation “barcodes” were read from 15,000 to 21,000 single cells from three human male brains. To overcome sparse sequencing coverage, the barcode had ∼31,000 rapidly fluctuating X-chromosome CpG sites (fCpGs), with at least 500 covered sites per cell and at least 30 common sites between cell pairs (average of ∼48). Barcodes appear to start methylated and record mitotic ages because excitatory neuro...
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Identifiers and source
- Literature Corpus work
- 97f8666d-4b61-522d-937f-29eb9ec45b62
- DOI
- 10.1101/2024.07.14.603450