Article

Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution

2023-09-17

Abstract excerpt

DNA-based evolutionary comparisons of regulatory genomic elements enable insight into functional changes, overcoming tissue inaccessibility. Here, we harnessed adult and fetal cortex single-cell ATAC-seq datasets to uncover DNA substitutions specific to the human and human-ancestral lineages within apes. We found that fetal microglia identity is evolutionarily divergent in all lineages, whereas other cell types ar...

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Literature Corpus work: a0dffadc-d0fc-5999-9c9e-f83e4ac3c033
DOI: 10.1101/2023.09.14.557820

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