Article
Somatic mutation in single human neurons tracks developmental and transcriptional history.
Science (New York, N.Y.) - 2 Oct 2015
Lodato Michael A, Woodworth Mollie B, Lee Semin, Evrony Gilad D, Mehta Bhaven K, Karger Amir, Lee Soohyun, Chittenden Thomas W, D'Gama Alissa M, Cai Xuyu, Luquette Lovelace J, Lee Eunjung, Park Peter J, Walsh Christopher A
Abstract excerpt
Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage. Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human brain. We identified thousands of somatic SNVs by single-cell sequencing of 36 neurons from the cerebral cortex of three normal individuals. Unlike germline and cancer SNVs, which are often caused by errors in DNA replication, neuronal...
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