Article

In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster

2026-02-23

Abstract excerpt

Resolving the lineage history of human cells is fundamental to understanding ageing and cancer but remains hampered by a lack of native, high-resolution markers. Here, we identify the protocadherin (PCDH) gene cluster as a naturally occurring, highly diverse methylation barcode. While PCDH methylation creates neuronal diversity in the brain, we show that stochastic methylation patterns in this region are maintaine...

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Literature Corpus work: 07b01654-3391-543d-b391-76ea9f451d2f
DOI: 10.64898/2026.02.23.707349

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