Article

Cell-type and cytosine context-specific evolution of DNA methylation in the human brain

2020-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Cell-type specific epigenetic modifications are critical for brain development and neuropsychiatric diseases. Here we elucidate evolutionary origins of neuron- and oligodendrocyte-specific DNA methylation in human prefrontal cortex, and demonstrate dynamic and distinctive changes of CG and CH methylation. We show that the human brain has experienced pronounced reduction of CG methylation during...

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Identifiers and source

Literature Corpus work: 63fd36ce-d243-512e-9954-98e89b41ec75
DOI: 10.1101/2020.07.14.203034

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