Article

Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain

2023-10-25

Abstract excerpt

Debate remains around anatomic origins of specific brain cell subtypes and lineage relationships within the human forebrain. Thus, direct observation in the mature human brain is critical for a complete understanding of the structural organization and cellular origins. Here, we utilize brain mosaic variation within specific cell types as distinct indicators for clonal dynamics, denoted as cell-type-specific Mosaic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b1eaafd-5287-5279-a00d-b2c9e28aa263
DOI: 10.1101/2023.10.24.563814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrainDOI 10.1101/2023.10.24.563814Read

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain.Semantic proximity Read

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical developmentSemantic proximity Read

Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.Semantic proximity Read

Parallel RNA and DNA analysis after Deep-sequencing (PRDD-seq) reveals cell type specific lineage patterns in human brainSemantic proximity Read

Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.Semantic proximity Read

Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortexSemantic proximity Read

Disease insights from brain somatic mosaicism.Semantic proximity Read

Cell lineage analysis in human brain using endogenous retroelements.Semantic proximity Read

Genomic mosaicism in the developing and adult brainSemantic proximity Read

Genomic mosaicism reveals developmental organization of trunk neural crest-derived gangliaSemantic proximity Read

Somatic mutation in single human neurons tracks developmental and transcriptional history.Semantic proximity Read

Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific ExpressionSemantic proximity Read