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Article

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain.

Nature - 1 May 2024

Chung Changuk, Yang Xiaoxu, Hevner Robert F, Kennedy Katie, Vong Keng Ioi, Liu Yang, Patel Arzoo, Nedunuri Rahul, Barton Scott T, Noel Geoffroy, Barrows Chelsea, Stanley Valentina, Mittal Swapnil, Breuss Martin W, Schlachetzki Johannes C M, Kingsmore Stephen F, Gleeson Joseph G

Abstract excerpt

Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain1-7. Thus, direct observation in the mature human brain is critical for a complete understanding of its structural organization and cellular origins. Here we utilize brain mosaic variation within specific cell types as distinct indicators for clonal dynamics, denoted as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38600385
DOI: 10.1038/s41586-024-07292-5
PMCID: PMC11194162

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DLX1

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