Article

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome

2026-02-19

Abstract excerpt

Healthy brain development requires a coordinated process of postnatal cellular maturation throughout the first two decades of life that transforms neuronal morphology, connectivity, physiology, and gene expression. The maturation and stable maintenance of neuron identity is driven, in part, by large-scale reconfiguration of the neuronal DNA methylome. Neurons have uniquely high levels of 5-hydroxy-methyl-cytosine...

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Literature Corpus work: 8cb43e56-ccbf-54df-8844-1122fe5d31ed
DOI: 10.64898/2026.02.18.706675

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