Article
Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development
2020-08-10
Abstract excerpt
The structure of the human neocortex underlies species-specific features and is a reflection of intricate developmental programs. Here we analyzed neocortical cellular lineages through a comprehensive assessment of brain somatic mosaicism—which acts as a neutral recorder of lineage history. We employed deep whole genome and variant sequencing in a single postmortem neurotypical human brain across 25 anatomic regi...
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Identifiers and source
- Literature Corpus work
- 87c9cfbb-7d2c-5f59-aed2-600ecbb7d08b
- DOI
- 10.1101/2020.08.10.244814