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Genomic mosaicism in the developing and adult brain

20 Jul 2018

Abstract excerpt

Since the discovery of DNA, the normal developing and functioning brain has been assumed to be composed of cells with identical genomes, which remains the dominant view even today. However, this pervasive assumption is incorrect, as proven by increasing numbers of reports within the last 20 years that have identified multiple forms of somatically produced genomic mosaicism (GM), wherein brain cells-especially...

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PMID: 30027562
DOI: 10.1002/dneu.22626

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