Article

Divergent neuronal DNA methylation patterns across human cortical development: Critical periods and a unique role of CpH methylation

2018-09-29

Abstract excerpt

We have characterized the landscape of DNA methylation (DNAm) across the first two decades of human neocortical development in NeuN+ neurons using whole-genome bisulfite sequencing and compared them to non-neurons (primarily glia) and prenatal homogenate cortex. We show that DNAm changes more dramatically during the first five years of postnatal life than during the entire remaining period. We further refined glob...

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Literature Corpus work: 5702284a-042b-56e9-81d1-2fbc2a5f6ea5
DOI: 10.1101/428391

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