Article

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

2020-08-15

Abstract excerpt

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing and fork directionality profiles obtained by RNA-seq, Repli-seq and OK-seq. ORC and MCM are strongly and homogeneously depleted from transcribed genes, enriched at gene prom...

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Identifiers and source

Literature Corpus work: 9768e5fd-cf98-54ef-9e21-027a91e21b94
DOI: 10.1101/2020.08.15.252221

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