Article

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping

2017-11-06

Abstract excerpt

The timing of DNA replication is largely regulated by the location and timing of replication origin firing. Therefore, much effort has been invested in identifying and analyzing human replication origins. However, the heterogeneous nature of eukaryotic replication kinetics and the low efficiency of individual origins in metazoans has made mapping the location and timing of replication initiation in human cells dif...

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Literature Corpus work: 2b6d8879-a29e-52a7-a130-a2df1cb76c1c
DOI: 10.1101/214841

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