Article

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

2021-12-15

Abstract excerpt

In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively. It is debated which of these two temporally separate steps determines origin efficiency. Experiments can independently profile mean replication timing (MRT) and replication fork directionality (RFD) genome-wide. Such pro...

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Literature Corpus work: d1ea211e-17a8-5d3a-a577-e7a36bd7832c
DOI: 10.1101/2021.12.15.472795

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