Article

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control

2021-05-14

Abstract excerpt

DNA replication initiates from replication origins firing throughout S phase. Debate remains about whether origins are a fixed set of loci, or a loose agglomeration of potential sites used stochastically in individual cells, and about how consistent their firing time is. We developed an approach to profile DNA replication from whole-genome sequencing of thousands of single cells, which includes “ in silico flow c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f858020-9ebe-57f6-bc34-f73858463e7c
DOI: 10.1101/2021.05.14.443897

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlDOI 10.1101/2021.05.14.443897Read

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication MappingSemantic proximity Read

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read

DNA replication timing reveals genome-wide features of transcription and fragilitySemantic proximity Read

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read

Acceleration of genome replication uncovered by single-cell nascent DNA sequencingSemantic proximity Read

Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation SequencingSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

The Genomic Architecture of Human DNA Replication OriginsSemantic proximity Read

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem CellsSemantic proximity Read

Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies <i>MCM10</i> as a novel regulator of the replication programSemantic proximity Read

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read