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Article

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

6 Dec 2009

Abstract excerpt

Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach--Repli Seq--to map temporally ordered replicating DNA using massively parallel sequencing and applied it to study regional variation in human DNA replication time across multiple...

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PMID: 19966280
DOI: 10.1073/pnas.0912402107

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