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Transcription shapes DNA replication initiation to preserve genome integrity

9 Jun 2021

Abstract excerpt

BACKGROUND: Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage. RESULTS: We develop a high-throughput nucleoside analog incorporation sequencing assay and identify thousands of early replication initiation zones in both mouse and human...

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PMID: 34108027
DOI: 10.1186/s13059-021-02390-3

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