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Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

31 Aug 2023

Abstract excerpt

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ~50,000 origins on human chromosomes in each cell cycle. The origins are believed to be specified by binding of factors like the origin recognition complex (ORC) or CTCF or other features like G-quadruplexes. We have performed an integrative analysis of 113 genome-wide human origin profiles (from five...

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PMID: 38567819
DOI: 10.7554/elife.89548

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