Article

How MCM loading and spreading specify eukaryotic DNA replication initiation sites

2016-08-24

Abstract excerpt

DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are randomly located in early fly and frog embryos, which do not transcribe their genomes, and are clustered in broad (10-100 kb) non-transcribed zones, frequently abutting transcribed genes, in mammalian cells. Nonetheless, in all cases, origins are established d...

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Literature Corpus work: 2acb7808-b011-5e6f-ab38-f6a54efa4bee
DOI: 10.12688/f1000research.9008.1

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