Article

Integrating process, proximity, and prediction implicates novel protein and RNA interactions in human Origin Recognition Complex function

2025-05-30

Abstract excerpt

Genome replication start sites, called origins, begin to be specified by Origin Recognition Complex (ORC) proteins prior to replication through a process called origin licensing. Once licensed, origins become active and initiate DNA synthesis with varying efficiencies influenced by local chromatin environment, transcription, and 3D genome organization. ORC proteins have also been implicated in regulating chromatin...

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Literature Corpus work: 0e5592a2-58e5-5240-b0b3-3d1bb4526953
DOI: 10.1101/2025.05.28.651956

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