Article

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

2019-09-23

Abstract excerpt

Eukaryotic replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with replication initiation events obtained by Okazaki fragment sequencing. We demonstrate that MCM is displaced from early replicating, actively transcribed gene bodies, while ORC is mainly enriched at active TSS. Lat...

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Literature Corpus work: 3c2b5b4d-5a3a-556e-b8eb-fc5098b85411
DOI: 10.1101/778423

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