Article

DNA replication timing reveals genome-wide features of transcription and fragility

2024-11-25

Abstract excerpt

DNA replication in humans requires precise regulation to ensure accurate genome duplication and maintain genome integrity. A key indicator of this regulation is replication timing, which reflects the interplay between origin firing and fork dynamics. We present a high-resolution (1-kilobase) mathematical model that maps firing rate distributions to replication timing profiles across various cell lines, validated u...

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Literature Corpus work: e64fffef-f341-5b64-8716-b7e68059829e
DOI: 10.1101/2024.11.25.625090

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