Article

DnaJC7 specifically regulates tau seeding

2023-03-16

Abstract excerpt

Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large families of chaperone proteins, including Hsp70s and J domain proteins (JDPs) cooperate to regulate the folding of intracellular proteins such as tau, but the factors that coor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3eb7ac6-6691-5afd-ab71-c4d6a0778e24
DOI: 10.1101/2023.03.16.532880

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DnaJC7 specifically regulates tau seedingDOI 10.1101/2023.03.16.532880Read

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.Semantic proximity Read

VCP increases or decreases tau seeding using specific cofactorsSemantic proximity Read

Disruption of nuclear envelope integrity as a possible initiating event in tauopathiesSemantic proximity Read

VCP regulates early tau seed amplification via specific cofactorsSemantic proximity Read

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicitySemantic proximity Read

VCP regulates early tau seed amplification via specific cofactorsSemantic proximity Read

DnaJC7 in Amyotrophic Lateral Sclerosis.Semantic proximity Read

Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biologySemantic proximity Read

Tau: More than a microtubule‐binding protein in neuronsSemantic proximity Read

Regulation of physiological and pathological condensates by molecular chaperonesSemantic proximity Read

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.Semantic proximity Read

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative DiseasesSemantic proximity Read