Article

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

2022-02-19

Abstract excerpt

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of such aggregates has remained unclear, as specialized disaggregase chaperones are thought to be absent in mammalian cells. Here we show in cell culture and in neurons that the AAA+ chaperone VCP is recruited to...

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Identifiers and source

Literature Corpus work: 50dd0c81-d87f-5c03-9fb0-5d8c16852942
DOI: 10.1101/2022.02.18.481043

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