Article

B Cell Receptor Signaling Sets Boundaries for Selection of Broadly Neutralizing Antibody Functional Mutations

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> B cell signaling is required for germinal center (GC) selection and synergizes with T cell-help leading to differentiation into effector cells and a protective antibody response. Here, we studied the relationship between B cell signaling and the selection of functional mutations in a humanized mouse model of a CD4 binding-site specific HIV-1 broadly neutralizing antibody precursor. While BCR sig...

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Literature Corpus work: 94d75188-e9eb-581a-ab26-deb125c520d6
DOI: 10.64898/2026.08.13.744461

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