Article

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model

2026-04-01

Abstract excerpt

In germinal centers, activated B cells modify their antigen receptors through somatic hypermutation (SHM), followed by antigenic selection that favors expansion of high affinity B cells. The affinity maturation process is critical for development of broadly neutralizing antibodies (bnAbs) against the human immunodeficiency virus-1 (HIV-1). BnAbs have been isolated from some people living with HIV-1. Because these...

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Literature Corpus work: 17ce01ae-6337-55ce-8fe0-db352536d02b
DOI: 10.64898/2026.03.30.715358

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