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Article

Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates.

Cell - 25 Nov 2020

Viant Charlotte, Weymar Georg H J, Escolano Amelia, Chen Spencer, Hartweger Harald, Cipolla Melissa, Gazumyan Anna, Nussenzweig Michel C

Abstract excerpt

Immunological memory is required for protection against repeated infections and is the basis of all effective vaccines. Antibodies produced by memory B cells play an essential role in many of these responses. We have combined lineage tracing with antibody cloning from single B cells to examine the role of affinity in B cell selection into germinal centers (GCs) and the memory B cell compartment in mice immunized...

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Identifiers

PMID: 33125897
DOI: 10.1016/j.cell.2020.09.063
PMCID: PMC7722471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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