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Article

Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation

15 Dec 2017

Abstract excerpt

Two immunoglobulin (Ig) diversification mechanisms collaborate to provide protective humoral immunity. Combinatorial assembly of IgH and IgL V region exons from gene segments generates preimmune Ig repertoires, expressed as B cell receptors (BCRs). Secondary diversification occurs when Ig V regions undergo somatic hypermutation (SHM) and affinity-based selection toward antigen in activated germinal center (GC) B...

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PMID: 29247044
DOI: 10.1084/jem.20171022

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