Article

Germline-encoded specificities and the predictability of the B cell response

2022-09-19

Abstract excerpt

Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation. High-affinity antibodies to pathogens such as HIV, influenza, and SARS-CoV-2 are frequently reported to arise from B cells whose receptors, the precursors to antibodies, are encoded by particular immunoglobulin alleles. This raises the possibility that the pre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4b1892e-4f1a-5df9-ba86-550d4250f5f1
DOI: 10.1101/2022.09.16.508315

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline-encoded specificities and the predictability of the B cell responseDOI 10.1101/2022.09.16.508315Read

Germline-encoded specificities and the predictability of the B cell response.Semantic proximity Read

The evolution within usSemantic proximity Read

Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral DriftSemantic proximity Read

Trade-offs in antibody repertoires to complex antigensSemantic proximity Read

Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral driftSemantic proximity Read

Antigenic drift expands viral escape pathways from imprinted host humoral immunitySemantic proximity Read

The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.Semantic proximity Read

Somatic mutation, affinity maturation and the antibody repertoire: a computer model.Semantic proximity Read

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasisSemantic proximity Read

Replaying germinal center evolution on a quantified affinity landscapeSemantic proximity Read

Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.Semantic proximity Read

Regulated somatic hypermutation enhances antibody affinity maturationSemantic proximity Read