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Regulated somatic hypermutation enhances antibody affinity maturation

19 Mar 2025

Abstract excerpt

Abstract Germinal centres are specialized microenvironments where B cells undergo affinity maturation. B cells expressing antibodies whose affinity is improved by somatic hypermutation are selected for expansion by limiting numbers of T follicular helper cells. Cell division is accompanied by mutation of the immunoglobulin genes, at what is believed to be a fixed rate of around 1 × 10 −3 per base pair per cell...

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PMID: 40108475
DOI: 10.1038/s41586-025-08728-2

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