Article

B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models

2020-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Animal models of human antigen-specific B cell receptors (BCR) generally depend on “inferred germline” sequences, and thus their relationship to authentic naive human B cell BCR sequences and affinities is unclear. Here, BCR sequences from authentic naive human VRC01-class B cells from healthy human donors were selected for the generation of three new BCR knock-in mice. The BCRs span the physiol...

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Literature Corpus work: 8987e805-2e52-59c4-8a54-547101d4a48a
DOI: 10.1101/2020.02.24.963629

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B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse modelsDOI 10.1101/2020.02.24.963629Read

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