Article
Role of BCR affinity in T cell dependent antibody responses in vivo.
Nature immunology - 1 Jun 2002
Shih Tien-An Yang, Meffre Eric, Roederer Mario, Nussenzweig Michel C
Abstract excerpt
Antibody affinity for antigen is believed to govern B lymphocyte selection during T-dependent immune responses. To examine antibody affinity in T cell dependent immune responses, we compared mice that carry targeted V(H)B1-8 antibody genes with high or low antigen-binding affinity. We found that high- and low-affinity B cells had the same intrinsic capacity to respond to antigen, but in experiments where limiting...
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