Article

Context Dependent Perturbation of Allelic Expression Imbalance Reveals Novel Candidate Therapeutic Targets for Metabolic diseases

2023-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Obesity is a pivotal trigger for a spectrum of complex metabolic disorders. By colocalizing cis-eQTLs in adipose tissues from the GTEx consortium and trait-associated SNPs for complex traits from the GWAS Catalog within 3.6 million DNase I hypersensitive sites (DHSs), we systematically identify regulatory variants and genes that exhibit cis effects, as well as potential caus...

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Literature Corpus work: 944fcfcb-2a9f-5f3b-85aa-dfa17da38b74
DOI: 10.1101/2023.11.06.565672

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