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Article

Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity.

International journal of obesity (2005) - 1 Mar 2019

Dong Shan-Shan, Yao Shi, Chen Yi-Xiao, Guo Yan, Zhang Yu-Jie, Niu Hui-Min, Hao Ruo-Han, Shen Hui, Tian Qing, Deng Hong-Wen, Yang Tie-Lin

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified many susceptibility loci for obesity. However, missing heritability problem is still challenging and ignorance of genetic interactions is believed to be an important cause. Current methods for detecting interactions usually do not consider regulatory elements in non-coding regions. Interaction analyses within chromatin regulatory circuitry may identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29717274
DOI: 10.1038/s41366-018-0069-2
PMCID: PMC6298858

Genes

CAND2
RPL32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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