Article
Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.
Nucleic acids research - 7 Apr 2017
Lee Heekyoung, Qian Kun, von Toerne Christine, Hoerburger Lena, Claussnitzer Melina, Hoffmann Christoph, Glunk Viktoria, Wahl Simone, Breier Michaela, Eck Franziska, Jafari Leili, Molnos Sophie, Grallert Harald, Dahlman Ingrid, Arner Peter, Brunner Cornelia, Hauner Hans, Hauck Stefanie M, Laumen Helmut
Abstract excerpt
Genome-wide association studies identified numerous disease risk loci. Delineating molecular mechanisms influenced by cis-regulatory variants is essential to understand gene regulation and ultimately disease pathophysiology. Combining bioinformatics and public domain chromatin information with quantitative proteomics supports prediction of cis-regulatory variants and enabled identification of allele-dependent...
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