Article
Systematic functional characterization of non-coding regulatory SNPs associated with central obesity.
American journal of human genetics - 2 Jan 2025
Dong Shan-Shan, Duan Yuan-Yuan, Zhu Ren-Jie, Jia Ying-Ying, Chen Jia-Xin, Huang Xiao-Ting, Tang Shi-Hao, Yu Ke, Shi Wei, Chen Xiao-Feng, Jiang Feng, Hao Ruo-Han, Liu Yunlong, Liu Zhongbo, Guo Yan, Yang Tie-Lin
Abstract excerpt
Central obesity is associated with higher risk of developing a wide range of diseases independent of overall obesity. Genome-wide association studies (GWASs) have identified more than 300 susceptibility loci associated with central obesity. However, the functional understanding of these loci is limited by the fact that most loci are in non-coding regions. To address this issue, our study first prioritized 2,034...
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