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Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

15 May 2023

Abstract excerpt

DNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to investigate the impact of adipocyte DNA methylation variations in human obesity. We discover extensive DNA methylation changes that are robustly associated with obesity (N = 190 samples, 691 loci in subcutaneous and...

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PMID: 37188674
DOI: 10.1038/s41467-023-38439-z

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