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Article

Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.

Nature communications - 20 Apr 2026

Lee Seung Hyuk T, Kar Asha, Gelev Kyla Z, Chen Zeyuan Johnson, Das Sankha Subhra, Heinonen Sini, Saarinen Tuure, Vaittinen Maija, Kaminska Dorota, Peltoniemi Hilkka, Luo Chongyuan, Juuti Anne, Männistö Ville, Pihlajamäki Jussi, Kaikkonen Minna U, Pietiläinen Kirsi H, Balliu Brunilda, Pajukanta Päivi

Abstract excerpt

Obesity impairs subcutaneous adipose tissue function, which predisposes to chronic cardiometabolic comorbidities and accelerated biological aging. However, regulatory variants, their target genes and epigenomic landscape underlying this predisposition in each subcutaneous adipose tissue cell-type remain elusive. Our subcutaneous adipose tissue cell-type level cis-expression quantitative trait and colocalization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42010250
DOI: 10.1038/s41467-026-72248-4
PMCID: PMC13284207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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