Article
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.
Nature communications - 17 Apr 2018
Pan David Z, Garske Kristina M, Alvarez Marcus, Bhagat Yash V, Boocock James, Nikkola Elina, Miao Zong, Raulerson Chelsea K, Cantor Rita M, Civelek Mete, Glastonbury Craig A, Small Kerrin S, Boehnke Michael, Lusis Aldons J, Sinsheimer Janet S, Mohlke Karen L, Laakso Markku, Pajukanta Päivi, Ko Arthur
Abstract excerpt
Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating...
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