Article
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.
Nature genetics - 1 Jan 2025
Brotman Sarah M, El-Sayed Moustafa Julia S, Guan Li, Broadaway K Alaine, Wang Dongmeng, Jackson Anne U, Welch Ryan, Currin Kevin W, Tomlinson Max, Vadlamudi Swarooparani, Stringham Heather M, Roberts Amy L, Lakka Timo A, Oravilahti Anniina, Fernandes Silva Lilian, Narisu Narisu, Erdos Michael R, Yan Tingfen, Bonnycastle Lori L, Raulerson Chelsea K, Raza Yasrab, Yan Xinyu, Parker Stephen C J, Kuusisto Johanna, Pajukanta Päivi, Tuomilehto Jaakko, Collins Francis S, Boehnke Michael, Love Michael I, Koistinen Heikki A, Laakso Markku, Mohlke Karen L, Small Kerrin S, Scott Laura J
Abstract excerpt
Complete characterization of the genetic effects on gene expression is needed to elucidate tissue biology and the etiology of complex traits. In the present study, we analyzed 2,344 subcutaneous adipose tissue samples and identified 34,774 conditionally distinct expression quantitative trait locus (eQTL) signals at 18,476 genes. Over half of eQTL genes exhibited at least two eQTL signals. Compared with primary...
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