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Article

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci.

Nature communications - 6 Sept 2021

Joslin Amelia C, Sobreira Débora R, Hansen Grace T, Sakabe Noboru J, Aneas Ivy, Montefiori Lindsey E, Farris Kathryn M, Gu Jing, Lehman Donna M, Ober Carole, He Xin, Nóbrega Marcelo A

Abstract excerpt

Genome-wide association studies (GWAS) have identified many disease-associated variants, yet mechanisms underlying these associations remain unclear. To understand obesity-associated variants, we generate gene regulatory annotations in adipocytes and hypothalamic neurons across cellular differentiation stages. We then test variants in 97 obesity-associated loci using a massively parallel reporter assay and...

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Source

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Identifiers

PMID: 34489471
DOI: 10.1038/s41467-021-25614-3
PMCID: PMC8421397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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