Article

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation variations are prevalent in human obesity, but evidence of a causative role in disease pathogenesis is limited. In this study, we combine epigenome-wide association and integrative genomics to investigate the impact of subcutaneous and visceral adipocyte DNA methylation variations in extreme human obesity. We identify extensive DNA methylation changes that are robustly associated...

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Literature Corpus work: 5ec356e9-67fe-5a89-9392-0094f068b45c
DOI: 10.1101/2021.12.20.21266893

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