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Genome-wide colocalization of body fat distribution GWAS and subcutaneous adipose eQTLs identifies SNX10, DGKQ, and CBX3 as candidate causal genes for cardiometabolic disease

2026-06-15

Abstract excerpt

<h4>Background:</h4> Genome-wide association studies (GWAS) have identified hundreds of loci associated with body fat distribution, yet the causal genes and regulatory mechanisms through which these variants exert their effects remain largely unknown. Expression quantitative trait locus (eQTL) colocalization provides a powerful framework for identifying genes whose expression is genetically coregulated with compl...

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Literature Corpus work
0f4362da-e4a9-5601-b235-95b72356c751
DOI
10.64898/2026.06.13.26355580
Open publication

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Genome-wide colocalization of body fat distribution GWAS and subcutaneous adipose eQTLs identifies SNX10, DGKQ, and CBX3 as candidate causal genes for cardiometabolic diseaseDOI 10.64898/2026.06.13.26355580
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