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Article

Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights.

Free radical biology & medicine - 1 Apr 2025

Fu Liwan, Han Xiaodi, Wang Yuquan, Hu Yue-Qing

Abstract excerpt

OBJECTIVE: Obesity has a high heritability and frequently co-occurs with metabolic disorders, indicating shared genetic susceptibility. The underlying causative genes and biological mechanisms of obesity and metabolic disorders remain predominantly elusive. METHODS: The FinnGen R11 dataset, including over 450,000 subjects, was employed in conjunction with the Genotype-Tissue Expression Project (GTEx) v8 eQTls...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 39999931
DOI: 10.1016/j.freeradbiomed.2025.02.033

Genes

MAPRE3
MCM6
UBXN4

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