Article

Multiomic analysis of clonal development reveals new regulators of leukemic cell growth

2024-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Mechanisms driving the increase of cell growth in developing leukemia are not fully understood. We focused on epigenomic regulation of this process by analyzing the changes of chromatin marks and gene expression in leukemic cell clones as they progressed towards increased proliferation in a mouse model of acute myeloid leukemia (AML). This progression was characterized by gradual modulation of c...

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Literature Corpus work: 944a8ba5-e8ef-5c54-9b2e-dc000e699c36
DOI: 10.1101/2024.02.29.582846

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