Article

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

2022-05-18

Abstract excerpt

<h4>Summary</h4> Cancer evolution is a multifaceted process involving the acquisition of somatic mutations and progressive epigenetic dysregulation of cellular fate. Both cell-intrinsic mechanisms and environmental interactions provide selective pressures capable of promoting clonal evolution and expansion, with single-cell and bulk DNA sequencing offering increased resolution into this process 1-4 . Advances in...

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Literature Corpus work: 81c7bc5e-0909-5a6f-9beb-6d28659b3a94
DOI: 10.1101/2022.05.18.492524

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