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Article

Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia

30 Apr 2014

Abstract excerpt

BACKGROUND: Aberrant DNA methylation is frequently found in human malignancies including acute myeloid leukemia (AML). While most studies focus on later disease stages, the onset of aberrant DNA methylation events and their dynamics during leukemic progression are largely unknown. METHODS: We screened genome-wide for aberrant CpG island methylation in three disease stages of a murine AML model that is driven by...

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PMID: 24944583
DOI: 10.1186/gm551

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