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Article

Genetic variegation of clonal architecture and propagating cells in leukaemia.

Nature - 20 Jan 2011

Anderson Kristina, Lutz Christoph, van Delft Frederik W, Bateman Caroline M, Guo Yanping, Colman Susan M, Kempski Helena, Moorman Anthony V, Titley Ian, Swansbury John, Kearney Lyndal, Enver Tariq, Greaves Mel

Abstract excerpt

Little is known of the genetic architecture of cancer at the subclonal and single-cell level or in the cells responsible for cancer clone maintenance and propagation. Here we have examined this issue in childhood acute lymphoblastic leukaemia in which the ETV6-RUNX1 gene fusion is an early or ini...

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Source

Identifiers

PMID: 21160474
DOI: 10.1038/nature09650

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21160474-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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