Article

SKIDA1 transiently sustains MLL::ENL-Expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming

2025-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Infant leukemias arise as B-cell acute lymphocytic (B-ALL) or acute myeloid leukemia (AML). The majority are driven by chromosomal rearrangements of the MLL/ KMT2A gene ( MLL r) and arise in utero, implying a fetal cell of origin. Fetal and neonatal hematopoietic progenitors have unique transcriptomes and epigenomes, raising the question of whether MLL fusion proteins activate distinct target...

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Literature Corpus work: 9f9bcf8e-4210-52e0-8a9e-f396352df123
DOI: 10.1101/2025.04.12.648529

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