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Article

Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation.

Nature communications - 3 Nov 2021

Liu Yuxuan, Gu Zhimin, Cao Hui, Kaphle Pranita, Lyu Junhua, Zhang Yuannyu, Hu Wenhuo, Chung Stephen S, Dickerson Kathryn E, Xu Jian

Abstract excerpt

Cancers develop from the accumulation of somatic mutations, yet it remains unclear how oncogenic lesions cooperate to drive cancer progression. Using a mouse model harboring NRasG12D and EZH2 mutations that recapitulates leukemic progression, we employ single-cell transcriptomic profiling to map cellular composition and gene expression alterations in healthy or diseased bone marrows during leukemogenesis. At...

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Identifiers

PMID: 34732703
DOI: 10.1038/s41467-021-26582-4
PMCID: PMC8566485

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